AdvocureNF2NF2 Clinical Trials & Studies
Below is a list of clinical trials that are being held to treat tumors associated with NF2. Visit the links for more information.
As of Feb 2013
Currently Recruiting
Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma
ClinicalTrials.gov Identifier: NCT01345136
The purpose of the study is to determine if RAD001 treatment will shrink or slow the growth of the vestibular schwannoma(s) in Neurofibromatosis 2 (NF2) patients. Secondary objectives include determining if RAD001 treatment will improve hearing ability in NF2 patients.
Natural History Study of Patients With Neurofibromatosis Type 2
ClinicalTrials.gov Identifier: NCT00598351
This study will examine over the long-term the progress of patients with neurofibromatosis Type 2 (NF2), a condition associated with tumors of the nerves, brain and spinal cord. It will study patients' tumors to learn how fast they can grow and if certain factors might affect their growth. It will also examine the effects of the tumors on patients' abilities to carry out activities of daily living. (Most travel expenses are reimbursed.)
A Study of Nilotinib in Growing Vestibular Schwannomas
ClinicalTrials.gov Identifier: NCT01201538
The primary objective of this study is to evaluate the efficacy of Nilotinib in the treatment of patients with progressing VS. Secondary objectives of this study is to evaluate the toxicity profile, quality of life and symptom management of Nilotinib in the treatment of patients with progressing VS.
Bevacizumab (Avastin) in Treating Patients With Recurrent or Progressive Meningiomas
ClinicalTrials.gov Identifier: NCT01125046
This phase II trial is studying how well bevacizumab works in treating patients with recurrent or progression meningiomas.
Using Positron Emission Tomography (PET) to Predict Intracranial Tumor Growth in Neurofibromatosis Type II (NF2) Patients
ClinicalTrials.gov Identifier: NCT01222728
To use magnetic resonance imaging and positron emission tomography to better understand the growth of brain tumors in people with neurofibromatosis type II.
Concentration and Activity of Lapatinib in Vestibular Schwannomas
ClinicalTrials.gov Identifier: NCT00863122
This study is exploring whether a drug that is approved by the FDA and is currently used to treat breast cancer might also work to treat VS. This study will measure the amount of drug that travels from the bloodstream and arrives at the tumor.
Phase 2 Study of Bevacizumab in Children and Young Adults With Neurofibromatosis 2 and Progressive Vestibular Schwannomas (NF-2)K
ClinicalTrials.gov Identifier: NCT01767792 -- OPEN BUT NOT YET RECRUITING
To determine the hearing response rate at 24 weeks after treatment with bevacizumab for symptomatic vestibular schwannomas (VS) in children and young adults with NF2.
Neurofibromatosis Type 2 Associated Color Vision Anomalies and Birth Defects: Incidence and Insights
To determine the frequency of birth defects and miscarriages in patients with NF2, and to determine the frequency of color blindness in NF2 patients.
Auditory brainstem implant (ABI) patients needed for research study at MEEI and MGH
A clinical research study of patients who have an auditory brainstem implant (ABI) is being conducted jointly by researchers. We will use specialized hearing testing to better understand how your brain responds to stimulation from your ABI.
Sorafenib in a NF2 study, in the UK
Adults who have Neurofibromatosis 2 (NF2) and at least two skin tumours (nerve tumours under the skin also referred to as 'schwannomas') are invited to participate in a research study being undertaken in Plymouth and Manchester; Professor C. Oliver Hanemann, a consultant neurologist at the Peninsula College of Medicine and Dentistry in Plymouth, is the Chief Investigator. Professor Gareth Evans is the Principal Investigator in Manchester.
Ongoing but Not Recruiting
Bevacizumab (Avastin) for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2)
ClinicalTrials.gov Identifier: NCT01207687
This study is exploring whether a drug that is approved by the FDA and is currently used to treat other tumors might also work to treat VSs. Based on people who have taken this drug to treat VSs already, there is some reason to think that it might be helpful to certain people with NF2.
Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors
ClinicalTrials.gov Identifier: NCT00973739.
The purpose of this study is to determine if Lapatinib has any effect on tumors found in patients with Neurofibromatosis Type 2 (NF2). NF2 is a condition that mainly affects the skin and nervous system. It causes non-cancerous tumors (which are known as neuromas) to grow on the nerves around a person's body. Some signs of NF2 include a gradual loss of hearing and tumors growing on the skin, the brain and the spinal cord which can lead to complications.
Efficacy and Safety Study of RAD001 in the Growth of the Vestibular Schwannoma(s) in Neurofibromatosis 2 (NF2) Patients
ClinicalTrials.gov Identifier: NCT01490476
The purpose of the study (in France) is to determine if RAD001 treatment will shrink or slow the growth of the vestibular schwannoma(s) in Neurofibromatosis 2 (NF2) patients.
Phase II Study of Everolimus (RAD001) in Children and Adults With Neurofibromatosis Type 2
ClinicalTrials.gov Identifier: NCT01419639
This trial studies whether Everolimus is efficacious in treating neurofibromatosis 2.
Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma
ClinicalTrials.gov Identifier: NCT01125046.
The purpose of this study is to find out what effects, good and/or bad, sunitinib has on patients and their tumors. At this time, no drugs are routinely used to treat meningioma, hemangioblastoma or hemangiopericytoma. Only surgery and radiation therapy are known to be useful.
In addition:
For a comprehensive listing of U.S., International, and/or privately supported clinical trials, please see these websites below:
NOTE: try inputing "neurofibromatosis 2".... or a NF2 tumor tissue type such as "Vestibular Schwannoma", "Schwannoma", "Meningioma", "Glioma", "Ependymoma", or "Astrocytoma", within its respective search field.
Clinicaltrial.gov
Studies and trials with search of "NF2". A service of the U.S. National Institutes of Health.EU Clinical Trials Register
Studies and trials with search of "NF2".CERN Foundation
Collaborative Ependymoma Research Network (CERN). Clinical trials are an integral part of the CERN Foundation's many projects and collaboration. Our hope in these trials, and in all of our work, is to collect critical data that will advance a cure.-
Children's Tumor Foundation (CTF)
- Clinical Trials National Institute of Health (NIH)
Search the collection of research studies being conducted at the NIH Clinical Center. Developed by the National Library of Medicine.National Cancer Institute (NCI)
Search NCI's list of 8,000+ clinical trials now accepting participants.International Federation of Pharmaceutical Manufacturers & Associates (IFPMA)
FPMA Clinical Trials Portal ensures a free and easy-to-use interface for patients and health professionals alike to ongoing clinical trials, clinical trial results and complementary information on related issues. IFPMA Clinical Trials Portal is brought to you by IFPMA on behalf of its Member Companies and Associations.Clinical Trials Search
Find clinical trials by condition, sponsoring organization, or location. Detailed nationwide listings with recruitment status, contact information available free of charge.CenterWatch
CenterWatch lists more than 80,000 active clinical trials seeking study volunteers each month, making it the largest online and dynamic database of global clinical trials involving new drugs and devices regulated by the FDA and the Department of Health and Human Services.Virtual Trials
A premier source of information for brain tumors. As well as hosting many online support groups, chat rooms, newsletters, articles, and a database of clinical trials. Run by the Musella Foundation.